Smart Spectrophotometric Method Development for Simultaneous Estimation of Antidiabetic Drugs in Formulations

Abstract: Background: An anti-diabetic formulation consisting of vildagliptin and remogliflozin was prescribed for better glycemic control. In the present study a simple, rapid derivative spectrophotometric methods were evolved to analyze these two analytes from formulations. Methods: Two processed UV established by measuring peak amplitude at zero-crossing second spectra analytes. The procedure comprehends generation zero - order mixture analyte division multiplication pure remove effect one Results: Both showed linearity concentrations in range 2-75 ?g/ml RGF 2-50 VGT. low LOD LOQ found VGT both indicated good sensitivity methods. mean percentage recovery 98.60 % 100.78%, 98.81 99.15 VGT, with percent relative error. RSD intra inter-day precision less than ±2%. Finally, planned employed assay medicine outcomes matched reported Conclusion: results agreement concentration labeled amount no significant difference observed when compared method. Hence, anticipated procedures could be applied routine quality control formulations RGF. Key words: Antidiabetics, Vildagliptin, Remogliflozin, Derivative spectrophotometry, Formulation, Validation.